Fig. 2

Clec5a knockout improves the learning and memory deficit of the AD mouse model in the Morris water maze. (A) The mean daily escape latency in the 5-day hidden platform trial. (B) The representative paths are depicted during the probe trial. The dashed circle indicates the previous position of the platform. The pool is divided into four quadrants, delineated by dashed lines. The area where the platform was initially located is defined as the target quadrant. (C) The percentage of time spent in the target quadrant in the probe trial. (D) The swimming speed during the probe trial. n = 59 for WT, n = 42 for 5A^−/−, n = 23 for APP, n = 16 for APP5A^−/−. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001