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Table 5 Summary of the demographics and clinical data of MS and HAM participants

From: CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis

 

HC

MS

HAM

 Case no

67

113

29

CX3CR1+UCHL1+ (%)

0.24 ± 0.11

0.34 ± 0.39

0.65 ± 0.37

NMDAR2A (%)

1.22 ± 0.57

2.21 ± 1.01

3.69 ± 1.54

NFL (%)

1.43 ± 0.76

2.15 ± 1.25

3.69 ± 1.94

Age

mean = 25.86

range: 22–40

mean = 35.41

range: 9–71

mean = 50.07

range: 33–61

Sex (male: female)

10:57

32:81

5:24

Disease duration (year)

---

mean = 7.1

range: 0.1–23

mean = 10.04

range: 0–20

EDSS

---

3.1 ± 1.9

4.19 ± 1.33

Subtype (RRMS: PPMS: SPMS)

---

95:10:8

---

NFL (Simoa, pg/mL, n = 70)

---

25.13 ± 38.85

---

CSF HTLV-1 antibody

---

---

All (+)

Plasma HTLV-1 antibody

---

---

All (+)

PBMC virus titers

---

---

10.87 ± 6.89

  1. Note CX3CR1+/UCHL1+ (%), NMDAR2A (%), NFL (%), EDSS, NFL (Simoa, pg/mL, n = 70), and PBMC virus titers in the table are presented as mean ± SEM. EDSS = Expanded Disability Status Scale, RRMS = Relapsing Remitting Multiple Sclerosis, PPMS = Primary Progressive Multiple Sclerosis, SPMS = Secondary Progressive Multiple Sclerosis, CSF = Cerebrospinal Fluid, PBMC = Peripheral Blood Mononuclear Cell