CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis

Table 3 The differential genes between BV2 and RAW264.2 screened by mass spectrum

Confidence	Accession	Description	Coverage [%]	MW [kDa]	BV2/RAW264.7	p value
High	P35969	FLT1	4	149.8	100	1.23929E-16
High	Q9R0P9	UCHL1	14	24.8	100	1.23929E-16
High	P59764	DOCK4	1	226.4	100	1.23929E-16
High	O35099	MAP3K5	3	154.4	100	1.23929E-16
High	Q61666	HIRA	4	111.7	100	1.23929E-16
High	P98154	DGCR2	2	60.7	100	1.23929E-16
High	P70196	TRAF6	2	60	100	1.23929E-16
High	Q64685	ST6GAL	4	46.6	100	1.23929E-16
High	Q3UHC7	DAB2IP	3	131.6	100	1.23929E-16
High	Q9R0A0	PEX14	3	41.2	100	1.23929E-16

Note Coverage (%) represents how much percentage that the peptides fraction identified by mass spectrometry took up in the whole protein. MW = Molecular weight. Because the signals for certain proteins can be detected in BV2 EVs via mass spectrometry but not in RAW 264.7 EVs, the system defaults the fold change (BV2/RAW264.7) to 100

ISSN: 1742-2094