Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study

Table 2 Demographic and clinical data of SAH patients between non-hydrocephalus and hydrocephalus

	Non-hydrocephalus (n = 59)	Hydrocephalus (n = 13)	p value†
Baseline characteristics
Age (y)	59.8 ± 10.3	62.7 ± 15.1	0.403
Gender, male	27(45.8)	8(61.5)	0.303
BMI	23.1 ± 3.0	23.7 ± 3.7	0.961
Smoking	17(28.8)	4(30.8)	0.888
Drinking	16(27.1)	4(30.8)	0.790
Diabetes	4(6.8)	0(0)	0.999
Hypertension	28(47.5)	7(53.8)	0.677
Clinical data at admission
GCS grade	15(8–15)	15(8–15)	0.454
HH grade	2(2–4)	2(2–4)	0.468
Radiological data at admission
SEBES	3(1–4)	3(1–4)	0.579
IVH	25(42.4)	10(76.9)	0.024
Highest HU	68.6 ± 7.8	72.2 ± 6.7	0.121
Treatment
Coiling	21(35.6)	5(38.5)	0.845
Clipping	38(64.4)	8(61.5)	0.845
EVD	11(18.6)	7(53.8)	0.008
LD	48(81.4)	10(76.9)	0.715
Craniectomy	6(0)	2(15.4)	0.629
Complications
DCI	28(47.5)	12(92.3)	0.002
Seizure	2(3.4)	1(7.7)	0.455
Outcome
Length of hospital stay	14.3 ± 8.3	51.2 ± 66.7	< 0.001
GCS at discharge	15(8–15)	14(7–15)	0.010
3-month mRS (4–6)	22(37.3)	13(100)	< 0.001

Variables are presented as mean ± SD, median (interquartile range), or number (%)
† p values were calculated by Pearson chi-square test or Fisher’s exact test, or Student’s t test or Mann–Whitney U test as appropriate
SAH subarachnoid hemorrhage; BMI body mass index; CGS Coma Glasgow Scale; DCI delayed cerebral ischemia; HH Hunt-Hess; HU hounsfield unit; IVH intraventricular hemorrhage; EVD external ventricular drainage; LD lumbar drainage; mRS modified Rankin Scale

ISSN: 1742-2094