Fig. 6

EV-ATP content increased in CIE animals were diminished by pharmacologic or genetic P2 × 7R inhibition. The serum EV-ATP levels, upregulated 7–10-fold by CIE, were reduced in (A) BBG-treated–CIE-exposed and (B) P2 × 7R^−/− CIE-exposed mice. One-way ANOVA followed by Tukey’s post hoc test was used for the statistical analyses. n = 5–7, mean ± SEM and *p ≤ 0.05, **p < 0.01 and ***p < 0.001, ns = nonsignificant