Fig. 4

CIE exposure resulted in increased blood levels of P-glycoprotein (P-gp). The levels of plasma P-gp after CIE exposure were analyzed by ELISA. Plasma P-gp levels were significantly higher in the CIE-exposed mice than in air-control mice. Treatment with BBG had no effect on P-gp levels in the BBG-treated–CIE-exposed animals. Each bar represent mean ± SEM (n = 4–5), *p = 0.01, ***p < 0.0001. Two-way ANOVA analysis was applied to P-gp [interaction, F (1, 14) = 0.1159, p = 0.7386; raw factor, F (1, 14) = 1.1689, p = 0.2147; column factor, F (1, 14) = 83.91, p < 0.0001]