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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Fig. 3

Serum levels of P2 × 7R upregulated by CIE were suppressed by receptor inhibition. P2 × 7R shedding was significantly less in the serum in BBG-treated–CIE-exposed or P2 × 7R−/− CIE-exposed mice than in the serum of the CIE-exposed mice. Each bar represent mean ± SEM (n = 3–10), ***, p < 0.000. Two-way ANOVA was applied to P2 × 7R [interaction, F (2, 31) = 5.916, p = 0.0067; raw factor, F (2, 31) = 10.19, p = 0.0004; column factor, F (2, 31) = 10.19, p = 0.0224]

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Journal of Neuroinflammation

ISSN: 1742-2094