Fig. 8

STEP-mimetic attenuates exacerbation of ischemic brain injury in SHR rats. (A) SHR rats were subjected to MCAO (60 min) and reperfusion (RPF) for 24 h. STEP-mimetic (TAT-STEP-myc) was administered in a subset of SHR rats at the onset of reperfusion. (A) Neurological severity score was assessed 24 h after MCAO on a 5-point scale and represented as individual data points with median value. (B) Representative photomicrographs of TTC-stained brain slices (2 mm) show the extent of brain damage 24 h after ischemia and reperfusion. (C) Bar graphs represent quantitative analysis of the total infarct volume (mean ± SD, n = 6). (D) Line graphs represent area of infarction within each slice. Significant difference between means was assessed by student t-test and presented as *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001