Fig. 3

Further validation, external verification, and functional analysis of hub genes. A Correlations among the 16 hub genes. B Using was Cytoscape software to construct A PPI network. C Score of MCC algorithm in CytoHubba. D Determination of the soft-thresholding power (lambda = 0.15) and selection 4 genes through LASSO analysis. E The Venn diagram illustrates the intersection of LASSO with various PPI algorithms. F ROC curve of TLR4 and ALOX5 in the GSE75436 dataset and the external validation dataset. An AUC > 0.7 was considered to indicate good predictive performance. G In GSE75436, TLR4 and ALOX5 low expression groups were enriched in the myogenesis pathway