Fig. 7
Mouse brains supplemented with GAS6 were more resistant to JEV infection. Gas6 and GFP mice were infected with JEV at different MOIs via foot pad injection, and survival changes, behavioural scores, and weights in each group were recorded daily. A, B, C. Survival rates of gas6 and GFP mice infected with JEV at 107 PFU were 55.56% and 11.11%, respectively. The median survival time of the GFP mice was 10 days (left). The behavioural scores (B) and body weights (C) of each mouse were recorded until death. D, E, F. Survival rates of gas6 and GFP mice infected with JEV at 2 × 107 PFU were 55.56% and 11.11%, respectively. The median survival time of GFP mice was 11 days (left). The behavioural scores (E) and body weights (F) of each mouse were recorded until death. G, H, I. Survival rates of gas6 and GFP mice infected with JEV at 3 × 107 PFU were 22.22% and 0% respectively. The median survival times of the gas6 and GFP mice were 12 and 10 days, respectively. The behavioural scores (H) and body weight (I) of each mouse were recorded until death