Fig. 8
IL-11 and IL-11 + sIL-11Rα activate Müller cells in vivo. (A) Representative images of retinal cryosections of C57BL/6J mice 12 h after injection with IL-11, IL-11+sIL-11Rα or PBS control at OIR P12. Scale bar: 25 μm. (B) Representative higher magnification images of the ganglion cell layer, inner plexiform layer and inner nuclear layer after injection with IL-11 or IL-11+sIL-11Rα for better visualization of pSTAT3 Tyr705 and Isolectin co-staining. Scale bar: 25 μm. (C) Representative images retinal cryosections and of higher magnification images of C57BL/6J mice for GFAP 12 h after injection with IL-11, IL-11+sIL-11Rα or PBS control at OIR P12. Scale bar: 25 μm. (D) Representative images of retinal cryosections of ALDH1L1-GFP+ transgenic mice 12 h after injection with IL-11, IL-11+sIL-11Rα or PBS control at OIR P12. GCL = ganglion cell layer, IPL = inner plexiform layer, INL = inner nuclear layer, OPL = outer plexiform layer, ONL = outer nuclear layer. Scale bar: 25 μm