Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina

Fig. 3

IL-11 trans-signaling activates intracellular signaling pathways beyond STAT3. (A) Scatter plots with bar visualizing the JAK activation in HUVECs after stimulation with VEGF, IL-11+VEGF, sIL-11Rα+VEGF or IL-11+sIL-11Rα+VEGF for 15 min. Representative images of N = 3 independent experiments. (B) Scatter plots with bar visualizing activated signaling pathways in HUVECs after stimulation with VEGF, IL-11+VEGF, sIL-11Rα+VEGF or IL-11+sIL-11Rα+VEGF for 15 min. Representative images of N = 4 independent experiments. (C) Graphical summary of the activated pathways by IL-11 or IL-11+sIL-11Rα and their angiogenic effects in HUVECs. (D) Western blot of activated signaling pathways in HRMVECs after stimulation with VEGF, IL-11+VEGF, sIL-11Rα+VEGF or IL-11+sIL-11Rα+VEGF for 15 min. N = 1 experiment

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094