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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy

Fig. 3

TANs participate in malignant behaviors of glioma cells (A) NETs assist NE and MMP9 in the catabolism of Laminin, which ultimately promotes the arousal of dormant glioma cells and promotes glioma invasion. (B) TANs produce mtROS, NE, BMP2, TGF-β2, regulate ferroptosis resistance or ferroptosis of tumor cells promoting tumor proliferation. (C) TANs secrete BV8, IL-8, VEGFA, MMP14 and OPN, promoting tumor angiogenesis via influencing EC. Tumor cell-EC interaction reduces neutrophil recruitment. (D) TANs promote PMT of glioma

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Journal of Neuroinflammation

ISSN: 1742-2094