Fig. 2

Depletion of cochlear macrophages in CSOM improves OHC survival. Wholemount samples of the cochlea (basal, middle, and apical turn) are shown in control (top row) and PLX5622 treated (bottom row) mice in CSOM at 7d (A-C and G-I) and 14d (D-F and J-L). (M) The OHC survival rate in % was compared to OHC in healthy cochlear basal turn at 14d. The OHC survival rate was significantly higher in PLX5622 treated CSOM compared to control CSOM. The number of mice per group is shown in Parentheses. The data represents mean +/- SD. Red = Myosin VIIa. Arrows show HC loss. Scale bar = 100 μm