Fig. 1

Macrophages are reduced following PLX5622 treatment in CSOM. Cryosections of the cochlea (basal, middle and apical turn) are shown in control (left) and PLX5622 treated (right) CSOM mice at different timepoints: 7d (A-F) and 14d (G-L). Panel M shows a significant decrease in the number of macrophages per turn at 7d (p ≤ 0.001) and 14d (p < 0.001) in the PLX5622 treated group. The number of mice per group is shown in parentheses. The data represents mean +/- SD. Red = F4/80 (arrows). Scale bar = 100 μm