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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment

Fig. 1

scRNA-seq identified of a unique LILRB4+ microglia subtype associated with stroke. (A) Spatial transcriptomics analysis of LILRB4 expression in the ischemic hemisphere in mice after stroke. (B) t-SNE plots showing the disease origin and the distribution of microglia. (C) Histograms of subcellular components in the control and deletion groups. (D) The t-SNE diagram showing that LILRB4 is expressed mainly in MG3. (E) Violin plot depicting the LILRB4 expression profile of microglia subtypes. (F) Heatmap of differentially expressed genes between LILRB4+ microglia subtype and WT steady state microglia. (G) Selected significantly enriched pathways by gene set enrichment analysis between LILRB4+ microglia and WT subtype

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Journal of Neuroinflammation

ISSN: 1742-2094