Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain

Rowe, Cassie J.; Nwaolu, Uloma; Martin, Laura; Huang, Benjamin J.; Mang, Josef; Salinas, Daniela; Schlaff, Cody D.; Ghenbot, Sennay; Lansford, Jefferson L.; Potter, Benjamin K.; Schobel, Seth A.; Gann, Eric R.; Davis, Thomas A.

doi:10.1186/s12974-024-03205-5

Journal of Neuroinflammation

Table 1 Functional group analyses of differentially expressed genes (DEGs) determined in different brain regions for each injury group

From: Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain

	6 h					24 h					168 h
	BOP	BU	CEI+tI+HLA	BOP+BU	BOP+CEI+dHLA	BOP	BU	CEI+tI+HLA	BOP+BU	BOP+CEI+dHLA	BOP	BU	CEI+tI+HLA	BOP+BU	BOP+CEI+dHLA
Apoptosis	Pycard Tnf	Casp7 Casp8 Pycard Tnf Tp53	Bcl2 Tp53	Bcl2 Casp7 Casp8 Casp9 Tp53	Bcl2 Casp3 Casp7 Casp8 Pycard		Bcl2 Casp1 Casp7 Casp8 Pycard	Bcl2 Casp1 Pycard Tp53	Casp1 Tnf	Bcl2 Casp1 Casp3 Casp7 Casp8 Casp9	Bcl2 Casp8 Pycard Tp53	Casp1 Casp3 Casp8 Casp9	Bcl2 Casp1 Caps7 Casp8 Pycard Tnf	Pycard	Bcl2 Casp3 Casp7 Casp8 Casp9 Pycard Tp53
Chemoattractant		Ccl3 Ccl5 Cxc10 Il16	Ccl3 Ccl5 Cxc10 Il16	Cxcl10	Ccl5 Cxcl10	Ccl5 Cxcl10 Il16	Ccl3 Ccl5 Cxcl10	Ccl3 Cxcl10	Ccl5 Cxcl10	Ccl3 Ccl5 Cxcl10 Il16	Il16	Ccl3 Ccl5		Cxcl10 Il16	Ccl5 Cxcl10 Il16
Chemokine/Chemokine Receptors	Ccl2 Ccl4 Cxcl9 Cxcr2	Ccl19 Ccl2 Ccl4 Cxcl9 Cxcr2	Ccl2 Cxcr2	Ccl19 Ccl4 Cx3Cl1 Cxcl5 Cxcl9 Cxcr2	Ccl19 Ccl2 Ccl5 Cxcl5 Cxcl9 Cxcr2	Ccl19 Cxcl9	Ccl19 Ccl2 Ccl20 Ccl4 Cxcr2	Ccl19 Ccl2 Ccl4 Cxcl5 Cxcl9	Ccl19 Ccl4 Cx3Cl1 Cxcl9	Ccl2 Cxcl1 Cxcl5	Ccl4 Cxcl1 Cxcl12 Cxcl9	Ccl19 Ccl4 Cxcl5 Cxcr2	Cxcl12 Cxcl5 Cxcl9	Cx3Cl1 Cxcl5 Cxcl5 Cxcl9 Cxcr2	Ccl19 Cxcl1 Cxcl12 Cxcl5 Cxcl9
Cytokines	Il2	Il12a Il15 Il1b Il2 Il6 Tgfb2	Csf3 Il12a Il1a Il1b Il2 Il6 Tgfb1 Tgfb2	Csf1 Csf3 Il12a Il2 Il6 Tgfb2	Csf1 Il1b Il2 Il6 Tgfb1	Il15 Il1b Il2	Il12a Il15 Il1b Il2 Tgfb1 Tgfb2	Il12a Il15 Il1b Il2 Tgfb1 Tgfb2	Il12a Il1b Il2 Tgfb1 Tgfb2	Csf1 Il12a Il15 Il6 Tgfb1	Il12a Tgfb1	Il12a Il15 Il1a Il1b	Csf1 Csf3 Il12a Il15 Il1a Il1b Il2 Tgfb1 Tgfb2	Il12a Il2 Tgfb1 Tgfb2	Csf1 Il12a Il15 Il1b Tgfb1
Early Transcriptional Activators/TLRs	Fas Nos2	Cebpd Nfkb1 Tlr2 Tlr3	Cebpd Nfkb1 Nos2 Prkcq Tlr3 Tlr9	Cebpd Mapk10 Nfkb1 Rela Tlr2	Cebpd Mapk3 Nfkb1	Cebpd Fas	Cebpd Fas Mapk3 Nfkb1 Prkcq Rela Tlr3	Cebpd Nfkb1 Tlr3	Cebpd Fas Rela Tlr9	Cebpd Fas Lif Mapk10 Mapk3 Nfkb1 Tlr9	Cebpd Rela Tlr3	Nos2 Tlr2 Tlr3	Lif Nfkb1 Nos2 Tlr3	Nfkb1 Rela	Fas Lif Mapk10 Mapk3 Nfkb1 Nos2 Tlr9
Immune Cell/Adhesion/Vascular Markers	Cd68	Cd14 Cd40 Cd86 Vcam1 Vegfa	Cd14 Itgam Vegfa	Cd14 Cd86 Icam1 Vegfa	Cd14 Cd86 Icam1 Itgam Vcam1	Cd68	Cd14 Cd40 Cd86 Icam1 Vcam1 Vegfa	Cd68 Vegfa	Cd86 Icam1 Vegfa	Cd14 Cd40 Icam1 Vegfa	Cd40 Cd68	Cd68 Vcam1 Vegfa	Icam1 Vcam1	Vegfa	Cd40 Icam1 Vcam1 Vegfa
Neurosteroids/Prostaglandins		Ptger2 Ptger3 Ptgs2	Cyp19a1 Gper1 Ptger3 Ptges2 Ptgs2	Cyp19a1 Gper1 Ptger2 Ptger3 Ptger4	Ptgs2	Ptger2	Ptger2 Ptger3 Ptgs2	Ptger3	Cyp19a1 Gper1 Ptger3	Cyp19a1 Gper1 Ptger2 Ptgs2	Cyp19a1 Ptger4 Ptges2 Ptgs2	Ptger2 Ptger3 Ptger4 Ptges2	Cyp19a1 Gper1	Cyp19a1 Ptger3	Gper1 Ptgs2
Neuronal Activity/Neuroinflammation/Neurodegeneration	Bdnf Grin1 Homer1	Dner Drd1a Gfap Homer1 Hpca Htr1a	Bdnf Dner Gabra1 Gfap Grin2b Hpca Htr1a Ntrk2	Bdnf Chi3l1 Drd1a Gfap Grin1 Grin2b Homer1 Htr1a	Bdnf Dner Gabra1 Gfap Grin1 Grin2a Grin2b Homer1 Ntrk2	Htr1a	Dner Gfap Homer1 Hpca Htr1a Ntrk2	Bdnf Dner Drd1a Gabra1 Gfap Grin2b Htr1a Htrk2	Bdnf Chi3l1 Dner Drd1a Gabra1 Bfap Grin1 Grin2b Homer1 Hpca Htr1a Ntrk2	Bdnf Dner Grin1 Grin2b Homer1 Hpca Ntrk2	Gfap Grin1 Homer1 Htr1a	Gfap Homer1 Htr1a	Grin1 Grin2b Homer1 Ntrk2	Gabra1Gfap Homer1 Htr1a	Bdnf Dner Grin1 Grin2b Homer1 Hpca Htr1a Ntrk2

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