Fig. 6

Neuroinflammatory gene signatures remain elevated at 168 hpi following various forms of trauma. The mean relative expression of individual genes across brain regions at 168 hpi, depicted by injury mode, was normalized to the geometric mean of three specific, constitutively active, and stable housekeeping genes (B2m, Gapdh, Hprt1) and regional brain biopsies from naïve uninjured animals. Two-way ANOVA was used to assess the main effect of injury on each of the brain regions. Tukey‒Kramer post hoc analyses were used to assess differences between injured and naïve expression changes. Asterisks (*) indicate significant differences from naïve uninjured controls. *p < .05, **p < .01, and ***p < .001