Fig. 5
Brain region-specific changes in neuroinflammatory gene transcript levels over time correlate with injury severity. Stacked bar charts are used to illustrate the number of differentially expressed genes (DEGs; up- or downregulated) in eight anatomical brain regions for each injury pattern. The data quantitatively reflect the number of genes with significant expression changes compared to those in naïve, uninjured control animals. The brain regions are displayed in ascending order based on the aggregate number of significantly altered genes (DEG counts irrespective of injury pattern and timepoint: cerebellum: 87, hippocampus: 96, amygdala: 98, striatum: 106, prefrontal cortex: 116, neocortex: 138, thalamus: 170, and hypothalamus: 180)