Fig. 2
Clinical indicators of systemic inflammation and remote organ dysfunction. a Changes in serum cytokine/chemokine levels were profiled in the naïve and trauma cohorts using a multianalyte MesoScale diagnostic profiling platform. b Serum chemical markers of end-organ damage were measured using a Heska Element DCX chemistry analyzer. Serum values from naïve animals (n = 7) were used to construct the 95% confidence intervals (gray shading). All the graphs show the mean values (n = 6–7 samples/timepoint/injury model) ± SEMs; significant differences (p < .05) in naïve animals are denoted with closed circles, and nonsignificant values are denoted with open circles at the indicated timepoints postinjury. The values were compared using one-way ANOVA and Tukey post-hoc analysis. Abbreviations: alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr)