Fig. 8

Tet1 knockdown alleviated IH-induced hippocampal neuroinflammation in mice. (A) The expression of Wnt3a, Ccnd2, and Prickle2 in the hippocampus using qPCR. Analysis was performed by Student’s t test. All experiments were repeated at least three times. All data are presented as the mean ± standard deviation. (B) Total amount of 5hmC in the hippocampus using standard DNA dot blot. (C) Differential expression of 23 cytokines was displayed by hierarchical clustering, and 13 of them were significantly upregulated after IH. Analysis was performed by Student’s t test. All data are presented as the mean ± standard deviation