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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit

Fig. 4

IH exposure promoted the binding of 5hmC to Wnt pathway genes in the hippocampi of mice. (A) The connection by assimilating RNA-sequencing data into methylation, demethylation and gene expression in promoter regions. (B) The expression of Wnt3a, Ccnd2, Prickle2, Il1b, Fgf13, Htr4, Adcy1, Snap25, and Syt1 in the hippocampus using qPCR. (C) 5hmC profiles of Wnt3a, Ccnd2, and Prickle2. (D) The demethylation levels of specific regions in Wnt3a, Ccnd2 and Prickle2 using hMeDIP-qPCR. Analysis was performed by Student’s t test. All data are presented as the mean ± standard deviation

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Journal of Neuroinflammation

ISSN: 1742-2094