Fig. 7

Altered abundance of DHA- and AA-containing phospholipids in response to amyloid and tau pathology. A. Heat map analysis of PCs, PEs, PSs, and SMs of 10- and 20-month-old McGill-R955-hTau, McGill-R962-hTau and age-matched wt rats (left) and of 6- and 16-month-old McGill-R-Thy1-APP and age-matched wt rats (right). Rows represent mean values of phospholipids and columns represent different ages and genotypes as indicated. B-C. Scatter plots of selected DHA- and AA-containing phospholipids show a decrease in DHA-containing phospholipids and an increase in AA-containing phospholipids in both APP and hTau rats. Two-group comparisons were performed with the Mann-Whitney U test. Kruskal-Wallis with Dunn’s post hoc tests was used for multiple comparisons. # p < 0.05, ### p < 0.001 compared to age-matched wt rats. * p < 0.05, ** p < 0.01 compared to other groups