Fig. 1

Schematic representation of the evolution of the amyloid and tau pathologies in the 3 lines of transgenic rats applied in this study. Note the accelerated tau pathology in R962- compared to the R955-hTau line. The time-points studied are indicated with red arrows in McGill-APP+/+ rats (6 and 16 months) and with red font in hTau rats (10 and 20 months)