Fig. 7

Pharmacological inhibition of poly (ADP-ribose) polymerase (PARP) with PJ34 improves locomotor performance in R778L mice. (A) Representative image of ionized calcium-binding adaptor molecule 1 (Iba1) staining in the brain. (B) Quantification of Iba1-positive cells and cell density per field in the striata of R778L and WT mice after PJ34 or vehicle treatment (n = 6 per group). (C) mRNA levels of Tnf in the striatum of R778L and WT mice following PJ34 or vehicle treatment (n = 6–8 per group). (D and E) The measurement of total distance, climbing behavior, and time spent in the center of R778L and WT mice following PJ34 or vehicle treatment, as assessed using the open-field test (n = 10 per group). (F) Escape latency in mice subjected to the Barnes maze test (n = 10 per group). The data are presented as the mean ± SEM and were evaluated using two-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons test. * p < 0.05, ** p < 0.01, *** p < 0.001 versus the mice treated with vehicle