Fig. 7

Sh-AKAP8L and rapamycin protected against neuronal damage and cognitive impairment in STZ mice. (a) Swimming trajectory images of the CON, STZ, STZ + sh-AKAP8L, and STZ + RAPA groups in the MWM test. (b) Escape latency during the training session. (c) Average speed of each group. (d) Statistical graphs of the time spent in the target quadrant. (e) Number of crossings over the original platform location. (f) Images and statistical graphs of NeuN immunofluorescence staining in the hippocampal CA1 region, representing the rate of viable neurons. (g) Images and statistical graphs of H&E staining in the hippocampal CA1 region, representing the rate of intact cells. (h) Images and statistical graphs of Nissl staining in the hippocampal CA1 region, representing the rate of intact neurons. Scale bar: 20 μm. Data are Mean ± SD (n = 6 or 12). P-values are from one-way or two-way ANOVA with Tukey post hoc multiple comparisons. **p < 0.01 compared to the Control group. ^##p < 0.01 compared to the STZ group