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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation

Fig. 7

ONX-0914 Reverses Mitophagy Induced by PA treatment (A) Representative confocal images of CLU177 cells treated with BSA or PA in the presence or absence of ONX-0914 for 24 h and transfected with mt-Keima were excited by the 440 and 586 nm laser. (B) Quantification of the number of acid puncta per cell (C) Schematic depiction of the ratiometric mitophagy reporter mt-Keima. Scale bar = 10 μm. Data are represented as mean ± SEM. Analysis: ONE-WAY ANOVA test. *p < 0.05, ***p < 0.001, ****p < 0.0001. n = 3

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Journal of Neuroinflammation

ISSN: 1742-2094