Fig. 8

Altered connectivity in the 5xFAD mouse is affected by FPI and CAP treatment. In (A), connectogram analysis revealed genotype differences between WT Sham + Veh and 5xFAD Sham + Veh mice, including reduced interhemispheric connections between the ACC (*). FPI in 5xFAD + Veh mice showed exacerbated connectivity. In 5xFAD FPI + CAP mice there was a further reduction in bilateral ACC connectivity but increased (presumably compensatory) connections bilaterally in RSC. In (B), tract shape analysis revealed that 5xFAD mice have greater tract curl than their WT counterparts. In 5xFAD FPI mice, CAP treatment significantly increased tract density relative to 5xFAD FPI + Veh- mice. In (C), 2D reconstructions of tracts illustrate the increased number of tracts in 5xFAD FPI + CAP mice compared to the paucity of tracts in the 5xFAD FPI + Veh mice. Note the increased tract plasticity in the peri-injury area. ACC – anterior cingulate cortex, BLA – basolateral amygdala, dHPC – dorsal hippocampus, IL – Infralimbic prefrontal cortex, PL – prelimbic prefrontal cortex, RSC – retrosplenial cortex, vHPC – ventral hippocampus