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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice

Fig. 7

FPI induces chronic alterations in cerebrovascular structure that are improved by CAP treatment. In (A-C), confocal micrographs of vessel painting in 5xFAD Sham + Veh (A), 5xFAD FPI + Veh (B), and 5xFAD FPI + CAP (C). Quantification showed that FPI significantly reduced junction density, vessel density, and average vessel length in the ipsilateral hemisphere (D-F). Vessel density and average vessel length were significantly increased in FPI + CAP mice (E, F). There were no significant changes identified in the contralateral hemisphere (G-I). Scale bars = 1000 μm. Data are represented as Mean ± SEM; n = 3 for all groups; *p < 0.05, **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094