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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice

Fig. 6

Reduced hippocampal neurogenesis in 5xFAD mice is improved by CAP and exacerbated by FPI. In (A-E), confocal micrographs illustrating DCX + immature neurons in the dentate gyrus of WT Sham + Veh (A), 5xFAD Sham + Veh (B), 5xFAD Sham + CAP (C), 5xFAD FPI + Veh (D), and 5xFAD FPI + CAP (E). In F, quantitative analysis shows a significant reduction in DCX + cells in the 5xFAD mice that is rescued by CAP. These results also show that FPI exacerbates the reduced hippocampal neurogenesis in 5xFAD mice, and CAP is unable to rescue this exacerbation. Qualitative analysis also reveals alterations in dendrites and their branching through the granule cell layer into the molecular layer in 5xFAD mice (yellow arrowhead) compared to WT (white arrowheads), and this change is partially restored with CAP treatment (green arrowheads). These areas of the images are enlarged in the insets. Data in F are represented as Mean ± SEM; n = 3–6; *p < 0.05, **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094