Fig. 4

Hippocampal β amyloid plaques in 5xFAD mice are altered by FPI and CAP in CA3. Representative micrographs of the DG (A-D), CA1 (E-H), and CA3 (I-L) are shown. There were no significant differences in the DG (M), or in CA1 (N). Conversely, in CA3 there was a significant increase in 5xFAD mice exposed to FPI (O), and CAP significantly prevents this FPI-induced increase in plaques. Scale bar in I = 100 μm for all micrographs. Data are represented as Mean ± SEM; n = 3 for vehicle groups, n = 6 for CAP groups; *p < 0.05