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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice

Fig. 12

Experimental design. Male 12-week-old wild type (WT) or 5xFAD mice received either fluid percussion injury (FPI) or sham surgery followed 30 min later by treatment with the CLIP antagonist peptide (CAP) or vehicle. Gait analysis was done at 1–5 days post injury (DPI). Depression-associated behavioral testing was done at 10 DPI and every 30 days thereafter. Cognitive testing started at 150 DPI. Tissue collection was done at 180 DPI when the mice were 9 months of age, and tissue was used for a number of pathological analyses including immunohistochemistry (IHC), flow cytometry, vessel painting (VP), and diffusion tensor imaging (DTI)

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Journal of Neuroinflammation

ISSN: 1742-2094