Fig. 11

5xFAD mice exhibit hippocampal-associated cognitive deficits. In (A-C), mice were challenged with the pattern recognition test (PRT). The results showed that a reduced percentage of 5xFAD Sham + Veh mice visit the NO first (A), and this effect was exacerbated by FPI. In (B), WT mice showed a significant preference for the NO that was not found in any of the 5xFAD groups. In (C), visits to the NO in PRT exhibited a significant negative correlation with the percentage of meningeal CLIP + B cells. In (D), 5xFAD mice had a longer average escape latency in the Barnes maze during the 4 training days, but this is not changed by FPI or CAP treatment. No significant differences were identified in the probe trials (E-G). It is pertinent to note that several mice did not visit the target quadrant for the full 3 min. Data are represented as Mean ± SEM; n = 6 for vehicle groups, n = 12 for CAP groups; *p < 0.05, **p < 0.01