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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice

Fig. 10

Differential effects of CAP on affect-associated behavior. In (A), 5xFAD mice exhibit reduced burrowing behavior compared to WT mice, including a significant reduction at 70 DPI and a trend at 130 DPI. Burrowing was reduced after FPI in 5xFAD mice at 10 DPI, but this was not altered by CAP treatment. In (B), CAP treatment differentially affects social interaction in 5xFAD mice. CAP increased social interaction in 5xFAD sham mice, most notably at 70 DPI, but reduces social interaction in 5xFAD FPI mice such that 5xFAD FPI + CAP mice exhibited significantly reduced interaction compared to 5xFAD Sham + CAP mice at 70, 100, and 130 DPI. In (C), regression analysis revealed a significant negative correlation between social interaction and meningeal CLIP + B cells. Data are represented as Mean ± SEM; n = 6 for vehicle groups, n = 12 for CAP groups; *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094