Fig. 2

High glycemic index diet (HGD) in males and ketogenic diet (KD) in females causes increased caspase-1 activation in the brain. A Representative images of caspase-1 biosensor mice with cranial windows at 26-weeks. B Cleaved caspase-1 signal was measured in mice at 10- and 26-weeks of age and the difference between the two time points was calculated for each animal. C Caspase-1 signal at 26 weeks in males and females. All data are shown as mean ± SEM and n = 4–11 per group. Statistical differences were determined using one-way ANOVA followed by a Dunnett’s test, comparing the HGD or KD to their sex-matched CD, where *, **p < 0.05 and 0.01 respectively