Fig. 1

Sheep serum and MMP9 positive immunohistochemistry

(A) Quantification of vessels with sheep serum immunopositive leakage and (B) quantification of MMP9 area coverage within vessels. Data are mean ± SD. Two-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.005. (C) Representative images of sheep serum extravasation from blood vessels into the brain parenchyma (black arrowhead), and sheep serum contained within the blood vessels (white arrowhead) in subcortical white matter (SCWM), periventricular white matter (PVWM) and caudate; and (D) representative images of MMP9 positive immunohistochemistry in the subcortical white matter (SCWM), periventricular white matter (PVWM). Scale bar represents 100 μm