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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming

Fig. 9

Proposed mechanisms for how hyperglycemia amplifies neuroinflammation sensitivity. Hyperglycemic conditions induced by streptozotocin promote astrocyte proliferation and reprogram homeostatic astrocytes into inflammatory phenotype in brains. Upon peripheral inflammation induced by lipopolysaccharide (LPS), reactive astrocytes augment LPS-induced blood-brain barrier (BBB) damages and myeloid cell infiltration into brains, which lead to neuroinflammation and the subsequent cognitive dysfunction

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Journal of Neuroinflammation

ISSN: 1742-2094