Fig. 5

The decrease in ammonia levels improved cognitive dysfunction and neuronal damage in CLP mice. (a) : T2WI, ASL, and DTI were perfected for 72 h after CLP surgery in each group. The red box shows the comparison of T2WI signal density and hippocampal rCBF. (b) : The Nissl staining of hippocampal tissues(DG, CA1, CA3) was perfected in each group. (c) : Evans blue dye extravasation was used to assess changes in vascular permeability in each group. (d) : Ammonia levels in the hippocampus and serum were compared between the CLP group and the CLP + FMT group. (e) : The novel object recognition was completed in each group of mice. (f) : The Morris Water Maze was completed in each group of mice.T2WI: T2-weighted imaging ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001