Fig. 9
Transplantation of MSCs decreased microglia activation and T cell infiltration. (A-E) Retinal sections from EAU mice transplanted with MSCtdTomato or MSCCCR5 cells, or administered with PBS were immunostained with antibodies against the indicated protein markers and counter-labeled with DAPI. Cd16/32 are markers for M1 microglia, F4/80 and Cd206 are markers for macrophages, and Tbx21, Foxp3 and Cd4 are markers for Th1 cells, Treg cells and T helper cells, respectively. (F) Quantification of Cd4-positive and Foxp3-positive cells in the indicated retinas. Data are presented as mean ± SEM. *p < 0.05, **p < 0.001 (n = 3 retinas per group). Scale bar: (A-E) 20 μm