Fig. 6

Chemokine signaling pathways were enriched in EAU retinas. (A, B) Chord diagrams comparing CC chemokine signaling pathway (A) and CXC chemokine signaling pathway (B) in control and EAU retinas. Edge color denotes the signaling source. Segments with large arrows represent signaling targets and inner bars represent signaling sources in which the colors indicate signaling targets. (C) Stacked violin plots showing the expression patterns of CC chemokine genes in control and EAU retinas based on scRNA-seq analysis. (D) Dot plot showing the expression of CC chemokine genes in control and EAU retinas based on bulk RNA-seq analysis. (E) qRT-PCR analysis showing the relative expression levels of the indicated CC chemokine genes in control and EAU retinas at 14 d.p.i. Data are presented as mean ± SD (n = 3 mice per group). *p < 0.05, **p < 0.01, ns, no significance. (F) Immunostaining of control and EAU retinal sections with an anti-CCL5 antibody with DAPI counter-labeling. Scale bar: (F) 20 μm