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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis

Fig. 3

Upregulation of MHC II genes in Müller glia of EAU retinas. (A) UMAP plots of Müller glia clusters in control and EAU retinas. (B) Stacked violin plots showing expression patterns of known Müller glia and astrocyte marker genes in different Müller cell clusters. (C) Feature plots comparing the expression of MHC II genes in control and EAU retinas. (D) Immunostaining of control and EAU retinal sections for MHC II proteins I-A/I-E with DAPI counter-labeling. (E) Triple-immunostaining of control and EAU retinal sections for GS (glutamine synthetase, red), MHC II proteins (I-A/I-E) (green), and Sox9 (magenta) with DAPI counter-labeling (blue). Arrowheads indicate representative GS+Sox9+MHC II+ triple-positive Müller glia. GCL: ganglion cell layer; INL: inner nuclear layer; ONL: outer nuclear layer. Scale bars: (D, E) 20 μm

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Journal of Neuroinflammation

ISSN: 1742-2094