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Table 3 Gene information for primary human astrocyte positive rhAbs

From: Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis

rhAb name

rhAb category

VH gene

JH gene

CDR3

AA length

CDR3

charge

VH

#RM

VL gene

JL gene

VL

#RM

Patient

PTM-2

VH3 + SHM−

VH3-7

JH6

25

0

0

VK1-39

JK5

0

PTM-A

PTM-4

VH3 + SHM+ 

VH3-7

JH4

10

0

11

VK2-30

JK4

2

PTM-A

PTM-6

VH3 + SHM+ 

VH3-30

JH4

20

1

9

VK1-27

JK5

4

PTM-B

PTM-9

VH4 + SHM−

VH4-39

JH4

19

1

0

VK3-20

JK2

0

PTM-B

PTM-12

VH4 + SHM+ 

VH4-4

JH4

14

− 3

5

VK3-11

JK2

9

PTM-C

  1. VH variable heavy, JH junction heavy, CDR3 complementarity determining region 3, AA amino acid, #RM number of replacement mutations, VL variable light
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Journal of Neuroinflammation

ISSN: 1742-2094