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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis

Fig. 6

Astrocyte binding rhAbs induce astrocyte stress, but not apoptosis. A Representative images of untreated and heatshock treated human primary astrocytes to demonstrate G3BP1 + puncta formation. White arrowheads indicate G3BP1 + puncta. B Representative images of primary human astrocytes incubated with PTM-6 or PTM-12 rhAbs showing induction of G3BP1 + puncta. Green: rhAb. Red: G3BP1. Blue: DAPI. Violet: Active caspase 3/7. In the merge panels, yellow indicates co-stain of G3BP1 with the rhAb. Scale bar: 20 μm. C Summary statistics for G3BP1 puncta + cells as an indication of stress. D Summary statistics for Caspase 3/7 + cells as an indication of apoptosis

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Journal of Neuroinflammation

ISSN: 1742-2094