Fig.4

Enrichment analysis of DEGs associated with HI. A Volcano map shows DEGs between sham vs HI group. Red: upregulated DEGs (P < 0.05, log2FC > 1); blue: downregulated DEGs (P < 0.05, log2FC < 1). B Hierarchical cluster analysis. Different columns in the figure represent different samples, and different rows represent different genes. The colors from blue to yellow indicate gene expression from low to high, respectively. C, D The bubble chart of GO and KEGG enrichment based on DEGs. The ordinate represents enriched GO functional and KEGG pathway terms of these DEGs, and the abscissa represents the –log 10 (P-values) of the significantly enriched terms. Counts represent the number of DEGs enriched in each GO functional or KEGG pathway term. E Heatmap showing the 22 DEGs associated with IL-1, IL-6, immune response and inflammatory response. F Heatmap showing the 17 DEGs associated with negative regulation of apoptotic, leukocyte activation and response to hypoxia