Fig. 5

P. copri treatment caused the changes in serum metabolomics in TBI mice. A. Hierarchical clustering analysis of serum metabolite biomarkers. The abscissa is the clustering of samples and the ordinate is the clustering of differential metabolites. The coloured blocks in different positions represent the content of the metabolites in the corresponding parts. Red means that the substance is highly expressed in the group where it is located, while blue means that the sense is poorly represented in the group where it is located. B. Venn diagram of differential metabolites in serum. C-D. Matchstick analysis of serum metabolite biomarkers. TBI + P. copri group vs. sham group (C), TBI + P. copri group vs. TBI group (D). Red nodes represent significantly upregulated metabolites (top 25), blue nodes represent significantly downregulated metabolites (top 25) (VIP > 1 and P < 0.05)