Fig. 5

Signaling changes of microglia subcluster during PHE tissue progression. (A) Cell ligand-receptor inference analysis of microglial subtypes during PHE tissue progression (G2 vs. G1). (B) Heatmaps demonstrate the differences in crosstalk strength of the SPP1 signaling pathway in microglial subclusters between different groups (G1, G2, and G3). (C)Â The contribution of inferred ligand-receptor pairs in SPP1 signaling between different groups (G1, G2, and G3)