Fig. 6
From: Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain
Effect of sulfasalazine administration on the spinal glial reactivity following PSNL surgery. Immunohistological staining of GFAP and Iba-1 was performed on lumbar spinal cord samples of xCT+/+ mice at 3 (A, B, C) and 7 days (A, D, E) after surgery. The fluorescent intensity for GFAP (B, D) and Iba-1 (C, E) in the dorsal horns was quantified. The results from the ipsilateral side are normalized and expressed as a percentage of the respective contralateral side. Images shown are representative of 4 different animals per group and histograms represent the geometric means with SD. Statistical analyses were performed using a one-way ANOVA model. GFAP glial fibrillary acidic protein; Iba-1 ionized calcium binding adapter protein 1; SAS sulfasalazine