Fig. 8
From: Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
Differences in the roles of OXR1 and OXR2. A, B Representative protein bands and quantitative analysis for OXR1, OXR2, and OXA in hippocampal tissue 24 h after CLP. C, D Representative protein bands and quantitative analysis of P-JNK, P-P38, IL-1β, and TNF-α after administration of SB-334,867 (OXR1 blocker) or JNJ10397049 (OXR2 blocker) 24 h after CLP. n = 3 per group. E, F Levels of IL-1β and TNF-α in brain tissue 24 h after CLP. n = 6 per group. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****P < 0.0001