Fig. 4
From: Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
OXA treatment for 7 days attenuates ultrastructural damage in septic mice. A Representative transmission electron micrograph of three groups of hippocampal neurons, blue arrow: endoplasmic reticulum. Scale bar = 5 μm. B Quantification of endoplasmic reticulum width in neurons. Values represent the mean of each group. n = 4 per group. C C is a magnified view of A. High magnification of neurons showing details of mitochondria, green arrows: mitochondria. Scale bar = 2 μm. D Representative electron micrographs of three groups of hippocampal synapses, red arrows: synaptic structures. n = 4 per group. Scale bar = 500 nm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****P < 0.0001