Fig. 8
From: Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis
Diagram of mechanism. In an inflammatory environment, resting microglia transform into activated microglia. The exosomes released by activated microglia can serve as their cellular communication with OPCs. In addition, miR-615-5p was expressed highly in activated microglia-derived exosomes, which silenced MYRF and ultimately led to the obstruction of OPCs differentiation